22 Nov 19

BioMin F is formulated in a different way from conventional toothpastes containing soluble fluoride. Instead, the particles of BioMin F bind to the tooth surfaces and dissolve slowly over several hours, releasing fluoride, calcium and phosphate, and laying down fluorapatite to mimic the formation of natural tooth mineral.

BioMin F is a unique toothpaste, developed in the laboratories of Queen Mary University London, to tackle the problems of demineralization of dental enamel and dentine hypersensitivity.

Dental erosion, exposure to acids in the mouth and other causes gradually lead to demineralization of tooth enamel, which in some cases can cause teeth to become ‘thinner’, more translucent or sensitive. A variety of toothpastes have been developed to combat these problems, but BioMin F works in a different way and is the first toothpaste to gain accreditation from the Oral Health Foundation’s expert panel for its effectiveness at both sensitivity reduction and remineralization.

Unlike conventional toothpastes containing soluble fluoride, which provide an instant but short-term ‘hit’ of fluoride, an optimal balance of calcium, fluoride and phosphate ions is an integral part of the structure of BioMin F. The BioMin F particles adhere to the tooth surfaces and gradually dissolve in saliva over several hours, releasing these ions to form fluorapatite, the fluoride analogue of natural tooth mineral. This is precipitated not just onto the surfaces of the teeth an independent study has shown that it penetrates deep into penetrates deep into enamel lesions to remineralize the sub-surface enamel1.

The researchers compared the remineralizing effectiveness of BioMin F with that of fluoride gel by applying both products to demineralized (white spot) lesions and found that the BioMin group showed significantly greater remineralization values.

They hypothesise that this was due to the low fluoride content of BioMin F, released gradually over several hours, which allows the penetration of the calcium and phosphate ions through the porous enamel sub-surface, effecting the successful remineralization of the demineralized enamel lesion, rather than simply restoring the surface layer. This biomimetic action (imitating a natural biochemical process) means that the fluorapatite that is formed is very similar to natural tooth mineral, and fluorapatite is more stable in the presence of acid than the hydroxyapatite formed by previous generations of bioactive glass compounds.

Dr Bakry, who led the trial, said: ‘We observed that there was a significant increase in mineral content within the lesions formed when we used the BioMin which may suggest that the BioMin paste may decrease lesion depth or completely remineralize the lesion depth if it is applied multiple times.’


1. Bakry AS et al. A novel fluoride containing bioactive glass paste is capable of re-mineralising early caries lesions. Materials (2018) 11 1636

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