Clinical Studies

Clinical Study PDFs (Complete)
Topic Document name Author Reference PDF or Website
Fluoride Comparative Evaluation of Retentive Levels of Fluoride in Saliva Following Toothbrushing with Sodium Fluoride and Fluoride Containing Bioactive Glass Dentifrices in Children - An Vivo Study. Dr.Aditi Garg, Dr.M. Ganesh, Dr.Vasudha Sodani, Dr. D.N. Kamala Heal Talk Link
Fluoride Comparative Evaluation of Fluoro Calcium Phosphosilicate, Calcium Sodium Phosphosilicate, and Strontium Chloride Hexahydrate containing Dentifrice for the Treatment of Dentin Hypersensitivity: A Randomized Single-Blind Shalini D Aggarwal, Anamika Borkar, Nikhil Borse, Aneesha Acharya Journal of International Oral Health Link
Fluoride Clinical Comparison of 5% Fluoro Calcium Phosphosilicate vs 5% Calcium Sodium Phosphosilicate in the treatment of Dentinal Hypersensitivity Dr. Huda Hussain, Prof. Suhail Majid Jan, Dr. Roobal Behal International Journal of Medical and Biomedical Studies Link
Fluoride A randomised clinical trail on the efficacy of 5% fluorocalcium phosphosilicate containing novel bioactive glass toothpaste Vivek Rajiv Patel, Leena Shetta, Srinath Thakur PubFacts - Scientific Publication Data Link
Fluoride Efficacy of a Fluoro-Calcium Phosphosilicate Dentrifice (Elsenz®) as compared to a Potassium Nitrate Dentrifice in the treatment of Dentinal Hypersensitivity: A Randomized controlled study Dr.Vaibhavi Bhatt, Dr.Asha Prabhu, Dr.Rahul Mehta, Dr.Meenu Pillai, Dr.Sushmita Bhakk and, Dr.Sweety Agarwal International Journal of Recent Scientific Research Link
Fluoride Comparative assessment of effectiveness of Biomin, NovaMin, herbal, and potassium nitrate desensitizing agents in the treatment of hypersensitive teeth Guntakala Vikram Reddy, Jayaprada Reddy Surakanti, Harikumar Vemisetty, Suryasowjanya Doranala, Jayasree Reddy Hanumanpally, Suryakanth Malgikar Journal of Dr. NTR University of Health Sciences Link
Fluoride Comparison of Clinical Efficacy Of Four Dentifrices In The Management Of Dentinal Hypersensitivity. Dr. Vanita Gautam, Dr. Hemant kumar halwai International Journal of Scientific Research Link
Fluoride Comparative Evaluation of Desensitizing Efficacy of Dentifrice Containing 5% Fluoro Calcium Phosphosilicate versus 5% Calcium Sodium Phosphosilicate: A Randomized Controlled Clinical Trial S. Ashwini, K. Swatika, D. N. Kamala Contemporary Clinical Dentistry Link

There are a number of on-going clinical studies on BioMin® containing toothpaste using commercially produced materials. The first to be published is;

Clinical Studies (Abstracts)

Gautam V and Kumar Halwai:
Comparison of Clinical Efficacy Of Four Dentifrices In the Management Of Dentinal Hypersensitivity.

IJSR - INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH Vol6. Issue-2. February 2017 ISSN no2277-8179 IF:3.508

Abstract Background:
Dentinal hypersensitivity (DH) is a painful response of a tooth to irritants such as toothbrushing, sweet or sour foods, and thermal changes. It is a cumbersome condition both for the patient and the dental care providers as well.

Aim:
To compare the clinical efficacy of four different commercially available dentifrices in the management of dentinal hypersensitivity.

Materials & Methods:
A total of 160 patients clinically diagnosed with dentinal hypersensitivity (93 males and 67 females) participated in this study. The participants were randomly divided into four groups:

  • Group 1: Toothpaste containing 5% Potassium Nitrate 
  • Group 2: Toothpaste containing 5% Fluoro Calcium Phosphosilicate 
  • Group 3: Toothpaste containing 10% Strontium Chloride
  • Group 4: A herbal formulation.

The patients' DH scores for tactile, thermal, and evaporative stimuli were recorded on a visual analog scale at baseline, 2 weeks, 1 month, and 2 months.

Results:
Symptoms of dentinal hypersensitivity were reduced in all four groups.
However, group 2 showed a better clinical response.

Conclusions:
The dentifrice containing Fluoro Calcium Phosphosilicate is more efficacious in managing dentinal sensitivity.

A randomised clinical trial on the efficacy of 5% Fluorocalcium Phosphosilicate containing novel bioactive glass toothpaste

J Oral Rehabil 2019 Jun 24. Epub 2019 Jun 24:
V.R. Patel, L. Shettar, S. Thakur Department of Periodontology and Implantology, Sri Dharmasthala, Manjunatheshwara College of Dental Sciences and Hospital, Dharwad, Karnataka, India.

Abstract:

Background and aim:
Dentin hypersensitivity (DH) is a common and harrowing dental condition. A Novel Biomin-F technology that contains 5% Fluorocalcium phosphosilicate bioactive glass has been introduced. It forms Fluorapatite which is more stable towards acid erosion. There is a lack of literature with the utility of this toothpaste in treating DH. Therefore, the authors of this randomized clinical trial have aimed to compare and evaluate the efficacy of 5% Fluorocalcium Phosphosilicate with an 8% Arginine and Calcium carbonate and Placebo toothpaste.

Methods:
A total of 75 patients clinically diagnosed with DH were randomly divided into Group A: 5% Fluorocalcium Phosphosilicate, Group B: 8% Arginine and Calcium carbonate, and Group C: Placebo. The DH was evaluated by tactile and evaporative stimuli and a visual analog scale (VAS) was used for evaporative stimuli at Pre-baseline, Baseline (15 days) and Post-baseline (1 month).

Results:
The results showed symptoms of DH were reduced in all three groups. However, Group A showed a better reduction of DH than the other two groups.

Conclusions: 
The toothpaste containing 5% Fluoro Calcium Phosphosilicate was reported to be more efficacious than the other two toothpastes in managing DH.

Practical Implications:
This novel development opens up a unique opportunity in the prevention and management of DH and may also be beneficial in preventing acid erosion of the tooth surface and in the maintenance of oral hygiene by reducing the effects of plaque accumulation and gingival inflammation. This article is protected by copyright. All rights reserved.