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Six-Month Clinical Evidence for Sustained Dentine Hypersensitivity Relief with BioMin® Toothpaste

MISHRA A, SURYAWANSHI V, THAPER R.
INT J COMMUNITY MED PUBLIC HEALTH. 2025;12(12):5747-5752. DOI

Method

This prospective observational study evaluated the long-term effectiveness, safety, and tolerability of a toothpaste containing fluoro-calcium phosphosilicate (BioMin® F) in 121 adults with dentine hypersensitivity (DH) across multiple dental clinics.

Participants (mean age 41.1 years) used the toothpaste twice daily for 24 weeks, with baseline oral prophylaxis performed as clinically indicated.

While the primary focus was dentine hypersensitivity, gingival health and supra-gingival plaque levels were also evaluated using the Modified Gingival Index (MGI) and the Turesky Modification of the Quigley–Hein Index (TMQHI).

Effectiveness was assessed using:

  • Schiff Cold Air Sensitivity Scale (SCASS)
  • Visual Analogue Scale (VAS) for dentine pain
  • Dentine Hypersensitivity Experience Questionnaire (DHEQ-15) for oral-health-related quality of life
  • Modified Gingival Index (MGI) for gingival health
  • Turesky Modification of the Quigley–Hein Index (TMQHI) for supra-gingival plaque

Assessments were conducted at baseline and at weeks 4, 6, 8, 12, 16, and 24. Safety and tolerability were monitored throughout the study.

Conclusion

Six months of twice-daily use of BioMin® F toothpaste use significantly and sustainably reduced dentine hypersensitivity and improved oral-health-related quality of life.

By week 24, patients demonstrated:

  • A −1.8 reduction in SCASS sensitivity scores (p<0.001)
  • A −57.9 reduction in VAS pain scores (p<0.001)
  • A −51.3 improvement in DHEQ-15 quality-of-life scores (p<0.001)

In addition to sensitivity relief, BioMin® F toothpaste delivered significant improvements in gingival health and plaque control, with both MGI and TMQHI scores improving by −1.8 at six months.

BioMin® F toothpaste was well tolerated, with no adverse events, and was rated excellent to very good by 89.9% of investigators and 83.2% of patients. The findings confirm its clinically proven, long-term (6-month) effectiveness for dentine hypersensitivity and support of overall oral health.

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